Marks and associates (2007) examined the potential utility of the investigational PCA3 urine assay to predict the repeat biopsy outcome. Urine was collected after DRE (3 strokes per lobe) from 233 men with serum PSA levels persistently ng/ml or greater and at least one previous negative biopsy. The PCA3 scores were determined using a highly sensitive quantitative assay with TMA. The ability of the PCA3 score to predict the biopsy outcome was assessed and compared with the serum PSA levels. The RNA yield was adequate for analysis in the urine samples from 226 of 233 men (., the informative specimen rate was 97 %). Repeat biopsy revealed prostate cancer in 60 (27 %) of the 226 remaining subjects. Receiver operating characteristic curve analysis yielded an area under the curve of for the PCA3 score. In contrast, the area under the curve for serum PSA was . Using a PCA3 score cutoff of 35, the assay sensitivity was 58 % and specificity 72 %, with an odds ratio of . At PCA3 scores of less than 5, only 12 % of men had prostate cancer on repeat biopsy; at PCA3 scores of greater than 100, the risk of positive biopsy was 50 %. The authors concluded that in men undergoing repeat prostate biopsy to rule out cancer, the urinary PCA3 score was superior to serum PSA determination for predicting the biopsy outcome. The high specificity and informative rate suggest that the PCA3 assay could have an important role in prostate cancer diagnosis.
Yet perhaps the biggest change coming with the Windows 10 Fall Creators Update is the rollout of Windows Mixed Reality. This is Microsoft’s long promised foray into consumer VR. While we’ve only seen a little of what this experience will look like we do know major computer makers like Dell, Acer, Lenovo, and HP are producing headset to work with Mixed Reality, and that unlike the Oculus Rift or HTC Vive, these headsets won’t require a bunch of extra cameras and IR sensors placed around the room to work properly. Headsets will start at $300, and many, like the Acer and HP headsets, will come in bundles including controllers based on a design Microsoft announced back into May .