Keep in mind the biggest filter organ in the body is the skin so when these toxins leak out of the contained system and into the bloodstream, they eventually make their way to the outer layer, the skin, and deposit the toxins on the surface of the skin causing itching, irritation, odor and then a secondary bacterial infections become a problem as well. Reoccurring ear infections are often treated with antibiotic, which don't even touch yeast infections of the ears, and in fact make it worse as it destroys the beneficial bacteria of the ear canal, altering the pH of the ear and making it comfy for yeast to want to grow there.
While the genetics of SLE are not very well understood, there is growing evidence for the involvement of specific genes in this complex autoimmune disease . Part of the complexity of this disease is due to the effects of both environment and genetics factors that may contribute to its development.  Further compounding our understanding of the etiology of the disease is the involvement of several organ systems.  Genetic studies of the rates of disease in families supports the genetic basis of this disease with a heritability of >66%.  Identical ( monozygotic ) twins were found to share susceptibility to the disease at >35% rate compared to fraternal ( dizygotic ) twins and other full siblings who only showed a 2–5% concordance in shared inheritance. 
Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.