Afimoxifene , [1] also known as 4-hydroxytamoxifen ( 4-OHT , 4-HT , OHTAM , others), is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and the major active metabolite of tamoxifen . [2] [3] The drug is under development under the tentative trademark TamoGel as a topical gel for the treatment of hyperplasia of the breast . [2] [4] It has completed a phase II clinical trial for cyclical mastalgia , [5] but further studies are required before afimoxifene can be approved for this indication and marketed. [4]

The chemical formulas for steroids and steroid-like substances are complex and often very difficult to distinguish without in-depth laboratory analysis. Anabolic steroids—compounds “designed” to behave like testosterone—and supplemental testosterone products are classified as “controlled substances” and are regulated by the Drug Enforcement Administration. If a specific steroid is on the . Drug Enforcement Agency’s list of “controlled substances,” then it is easy to identify, but even when a substance is not listed, it may still violate federal and state laws. In addition, the substance may be banned by most athletic associations. Also, because steroid-like substances can produce positive drug test results similar to those of anabolic steroids, we advise using extreme caution when considering any “dietary supplement” product labeled as containing steroid-like ingredients—including prohormones, testosterone “boosters,” “designer steroids,” and anything else compared to or purported to behave as any known anabolic steroid. In addition, little is known about their safety. For more information, check out the Food and Drug Administration article “Warning on Body Building Products Marketed as Containing Steroids or Steroid-Like Substances.”