ACTH stimulates secretion of the glucocorticoid steroid hormones from the adrenal cortex cells, especially in the zona fasciculata of adrenal glands. ACTH acts by binding to cell surface ACTH receptors, which are located primarily on the adrenocortical cells of the adrenal cortex. The ACTH receptor is a seven membrane spanning G protein- oupled receptor. Upon ligand binding, the receptor undergoes conformation changes to stimulate the enzyme adenylyl cyclase, which does lead to an increase in intracellular cAMP and subsequent activation of protein kinase.
5mg a day was too much and he was having bad side effects, extreme lethargy, he stopped eating,and drinking and his diarrhea actually got worse. Half a pill ever other day was not enough his stool was normal the first day then back to diarrhea the second. Half a pill mg a day seems to be the formula that works for him. He tolerates it well,and his stool remains normal. Mischief is much more active and healthy now,and is actually gaining weight. I am very pleased. Like I said I think it saved his life. Also the drug is very inexpensive $10 bucks a month
I have all these symptoms too... the heart palpitations, sweating, flushing, feeling extra emotional. My coworker said something to me that normally would not upset me and I started to have tears in my eyes and I couldn't help it at all I had to walk away. I thought it was probably all due to my anxiety but I've never experienced it like this before. I got 8 trigger point injections in my thoracic area on Friday, so it's almost been a week for me now. I am also wondering when my back pain should feel better?? My doctor also never told me any of this, I can't believe how common it seems to be!!