Nsaids non-steroidal anti-inflammatories

NSAIDS have antipyretic activity and can be used to treat fever. [75] [76] Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation. [75] [77] Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus . [75] [76] PGE2 signals to the hypothalamus to increase the body's thermal set point. [76] [78] Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen). [77] [79] Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.

Although different NSAIDs have different structures, they all work by blocking cyclo-oxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation.

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  • Citation tools Download this article to citation manager Day Richard O , Graham Garry G . Non-steroidal anti-inflammatory drugs (NSAIDs) BMJ 2013; 346 :f3195
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    Hi Norman, You might be interested in the following:
    1) Turmeric extract – See more information and studies in my article “ Turmeric Extract is Effective as Ibuprofen for Knee Osteoarthritis “.
    2) Gelatin – see more information and research in my article “ Gelatin and Osteoarthritis of the Knees “.
    3) Sesame seeds – more information in my article “ How To Use Sesame Seeds For Knee Osteoarthritis “.
    4) Tart cherries – see “ How to Fight Joint Pain and Inflammation With Tart Cherries “.
    5) Anti-Inflammatory Smoothie for Joint Pain .
    6) For pain relief – massaging the area with these 20 essential oils to relieve pain and inflammation , and/or consuming this anti-inflammatory and pain relieving turmeric ginger tea .
    7) See more possible natural treatments HERE , and HERE .

    Nsaids non-steroidal anti-inflammatories

    nsaids non-steroidal anti-inflammatories

    Hi Norman, You might be interested in the following:
    1) Turmeric extract – See more information and studies in my article “ Turmeric Extract is Effective as Ibuprofen for Knee Osteoarthritis “.
    2) Gelatin – see more information and research in my article “ Gelatin and Osteoarthritis of the Knees “.
    3) Sesame seeds – more information in my article “ How To Use Sesame Seeds For Knee Osteoarthritis “.
    4) Tart cherries – see “ How to Fight Joint Pain and Inflammation With Tart Cherries “.
    5) Anti-Inflammatory Smoothie for Joint Pain .
    6) For pain relief – massaging the area with these 20 essential oils to relieve pain and inflammation , and/or consuming this anti-inflammatory and pain relieving turmeric ginger tea .
    7) See more possible natural treatments HERE , and HERE .

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