After the molluscum bumps have resolved, persistent skin discoloration called hyperpigmentation may be left alone and allowed to resolve over time. Alternatively, residual hyperpigmentation may be treated with prescription fading creams like hydroquinone 4%, kojic acid, or azelaic acid 15-20%. Over the counter fading creams with 2% hydroquinone may be available like Porcelana. Specially designed prescription creams for particularly resistant skin discoloration using higher concentrations of hydroquinone 6%, 8%, or 10% with a retinoid and a topical steroid may also be formulated by compounding pharmacists. Mild chemical peels and microdemabrasion may also help improve discoloration.
Sex hormone-binding globulin (SHBG) is thought to mainly function as a transporter and reservoir for the estradiol and testosterone sex hormones. However it has also been demonstrated that SHBG can bind to a cell surface receptor (SHBG-R). The SHBG-R has not been completely characterized. A subset of steroids are able to bind to the SHBG/SHBG-R complex resulting in an activation of adenylyl cyclase and synthesis of the cAMP second messenger.  Hence the SHBG/SHBG-R complex appears to act as a transmembrane steroid receptor that is capable of transmitting signals to the interior of cells.