Dopamine is a multi-function neurotransmitter participating in the regulation of mobility, learning, emotions, appetite and positive reinforcing effects. It is an important neurotransmitter for operating the reward system, so dopamine is essential for addiction development. Serotonin, in turn, regulates sleep patterns, movement, appetite, sexuality and emotions. According to some studies, it is also related to memory operations and sustainable concentration.
Among other findings in animal experiments we’ve found that an anabolic steroid, nandrolone, changes the dopamine system response to stimulating intoxicants. The release of intoxicant-induced neurotransmitters lessens, and so does the pleasure procured from using intoxicants. (). In some studies, androgenic compounds have been shown to have direct activating functions for dopamine and serotonin release ().
In addition to the mentioned side effects several others have been reported. In both males and females acne are frequently reported, as well as hypertrophy of sebaceous glands, increased tallow excretion, hair loss, and alopecia. There is some evidence that anabolic steroid abuse may affect the immune system, leading to a decreased effectiveness of the defense system. Steroid use decreases the glucose tolerance, while there is an increase in insulin resistance. These changes mimic Type II diabetes. These changes seem to be reversible after abstention from the drugs.