Corticosteroid responsive dermatoses treatment

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In an embryofetal development study in pregnant rabbits, beclomethasone dipropionate administration during organogenesis from gestation days 7 to 16 at subcutaneous doses equal to and greater than  times the MRHDID in adults (on a mg/m 2 basis at maternal doses of  mg/kg/day and higher) produced external and skeletal malformations and embryolethal effects (increased fetal resorptions). There were no effects in fetuses of pregnant rabbits administered a subcutaneous dose  times the MRHDID in adults (on a mg/m 2 basis at a maternal dose of  mg/kg/day).

Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin), cholestyramine. May potentiate cyclosporine (seizure risk). May antagonize oral anticoagulants (monitor), isoniazid. Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics). Concomitant neuromuscular blocking agents; increased risk of myopathy. Withdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapy. Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression. Increased GI effects with aspirin, other NSAIDs. Caution with aspirin in hypoprothrombinemia. May suppress reactions to skin tests.

In two 12-week, placebo controlled studies (200109 and 200110), the addition of umeclidinium to fluticasone furoate/vilanterol (FF/VI) (92/22 micrograms) once daily in adult patients aged 40 years or over with a clinical diagnosis of COPD (mean post bronchodilatory screening FEV 1 45 and 47% of predicted, respectively; modified medical research council dyspnea score ≥2), resulted in statistically significant and clinically meaningful improvements in the primary endpoint of trough FEV 1 at Day 85 compared to placebo plus FF/VI (124 mL [95% CI: 93, 154, p<] in study 200109 and 122 mL [95% CI: 91, 152, p<] in study 200110).

Corticosteroid responsive dermatoses treatment

corticosteroid responsive dermatoses treatment

In two 12-week, placebo controlled studies (200109 and 200110), the addition of umeclidinium to fluticasone furoate/vilanterol (FF/VI) (92/22 micrograms) once daily in adult patients aged 40 years or over with a clinical diagnosis of COPD (mean post bronchodilatory screening FEV 1 45 and 47% of predicted, respectively; modified medical research council dyspnea score ≥2), resulted in statistically significant and clinically meaningful improvements in the primary endpoint of trough FEV 1 at Day 85 compared to placebo plus FF/VI (124 mL [95% CI: 93, 154, p<] in study 200109 and 122 mL [95% CI: 91, 152, p<] in study 200110).

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