Aminoglycosides such as neomycin are known for their ability to bind to duplex RNA with high affinity.  The association constant for neomycin with A-site RNA has been found to be in the 10 9 M −1 range.  However, more than 50 years after its discovery, its DNA-binding properties were still unknown. Neomycin has been shown to induce thermal stabilization of triplex DNA, while having little or almost no effect on the B-DNA duplex stabilization.  Neomycin was also shown to bind to structures that adopt A-form structure, triplex DNA being one of them. Neomycin also includes DNA:RNA hybrid triplex formation. 
As mentioned earlier, uric acid is only slightly soluble and individuals with impaired secretion or excess production of uric acid are subject to the pain of gout as uric acid precipitates in the joints. Most cases of gout are probably due to impaired excretion of uric acid because of poor kidney function. Because the concentration of uric acid in the blood is near the solubility limit, only a slight impairment of elimination can push the concentration high enough to precipitate uric acid. More frequently nowadays, gout appears in persons whose kidney function is impaired with age, although it is also found in individuals with genetic deficiencies in the level of hypoxanthine‐guanine phosphoribosyl transferase. In the latter case, the salvage pathway does not function well, and more purines must be eliminated through their conversion to uric acid.